Nx supports multiple frameworks including Angular, React, and Vue, making it suitable for large-scale applications that may use different technologies within the same workspace. It promotes a monorepo approach, allowing teams to share code and libraries effectively.

Create React App is specifically designed for React applications, providing a tailored environment that includes all necessary configurations for React development, such as Babel and Webpack.

Vue CLI is tailored for Vue.js applications, offering a powerful and flexible setup for Vue projects. It provides a plugin-based architecture that allows developers to customize their project setup easily.

Nx excels in customization and extensibility, allowing developers to create custom plugins and libraries. It provides advanced features like code generation and dependency graph visualization, making it a robust choice for complex applications.

Create React App offers limited customization options out of the box. However, it allows developers to eject the configuration if deeper customization is needed, although this can complicate the setup.

Vue CLI provides a highly customizable setup through its plugin system. Developers can easily add or remove plugins to suit their project's needs, allowing for a tailored development experience.

Nx has a steeper learning curve due to its extensive features and capabilities, which may require some time to fully understand, especially for teams new to monorepo management.

Create React App has a gentle learning curve, making it accessible for beginners who want to dive into React development without dealing with complex configurations.

Vue CLI is relatively easy to learn, especially for those familiar with Vue.js. Its straightforward command-line interface and plugin system make it approachable for new developers.

Nx has a growing community, particularly among enterprise-level applications. Its ecosystem includes a variety of plugins and tools that enhance development workflows, although it is less widespread than Create React App.

Create React App benefits from a large and active community, providing extensive documentation, tutorials, and third-party libraries that integrate seamlessly with React.

Vue CLI is backed by the Vue.js community, which is known for its strong support and resources. The ecosystem is rich with plugins and tools that cater specifically to Vue development.

Nx provides advanced performance optimization features, including dependency management and caching, which can significantly enhance build times and application performance in large projects.

Create React App includes performance optimizations such as code splitting and lazy loading by default, helping to improve application load times and overall performance.

Vue CLI allows for performance optimizations through its build configurations, including tree-shaking and code splitting, which help reduce the final bundle size and improve application speed.